Serie A official line-ups: Napoli vs. Lecce
Napoli give Andre Frank Zambo Anguissa his first start since November, as Alisson Santos supports Rasmus Hojlund against unpredictable Lecce.
It kicks off at the Stadio Diego Armando Maradona at 17.00 GMT (18.00 CET).
The Partenopei have the opportunity to consolidate third place after slender and hard-fought 2-1 wins over Verona and Torino.
Antonio Conte has yet more additions to the injury list, losing Antonio Vergara and Juan Jesus, with Stanislav Lobotka, David Neres, Giovanni Di Lorenzo and Amir Rrahmani already out.
Scott McTominay has been back in training since Tuesday and therefore gets a spot on the bench along with Kevin De Bruyne and Romelu Lukaku, both recovering from long-term injuries.
Lecce earned a potentially crucial 2-1 victory over Cremonese to drag them out of the bottom four.
Omri Gandelman has shaken off a knee problem, but Medon Berisha, Francesco Camarda and Kialonda Gaspar are out of action.
Nikola Stulic leads the attack with Lameck Banda, while Napoli-owned Walid Cheddira is on the bench.
Napoli vs. Lecce line-ups
Napoli: Meret; Beukema, Buongiorno, Olivera; Politano, Anguissa, Gilmour, Spinazzola; Elmas, Alisson Santos; Hojlund
Lecce: Falcone; Danilo Veiga, Siebert, Tiago Gabriel, Gallo; Coulibaly, Ramadani; Pierotti, Ngom, Banda; Stulic
Player statistic
| 3' | Jamil Siebert (Assist: Antonino Gallo) | |||
| 19' | Jamil Siebert |
| Rasmus Højlund (Assist: Matteo Politano) |
46' | |||
| Matteo Politano | 67' |