Serie A official line-ups: Roma vs. Inter
Roma welcome Paulo Dybala back in a False Nine role with Lorenzo Pellegrini and Matias Soulé, while Inter start Ange-Yoan Bonny with Lautaro Martinez and Hakan Calhanoglu.
It kicks off at the Stadio Olimpico at 19.45 UK time (18.45 GMT).
This is a potential head-to-head for the Scudetto, as the Giallorossi are joint top of the table alongside Napoli, with a strong start to life under new coach Gian Piero Gasperini.
Leon Bailey is on the bench for the first time since his transfer from Aston Villa, having sustained an injury in his maiden training session.
Angelino is out after flu symptoms deteriorated into bronchitis, so Wesley shifts across to the left flank, with Zeki Celik on the right.
The big surprise is that Dybala returns and is used as a False 9, seeing as both Artem Dovbyk and Evan Ferguson have struggled to make their mark this season.
He is supported by Pellegrini and Soulé, while Manu Koné starts in midfield after he was the subject of a big offer from Inter over the summer.
Inter are missing Marcus Thuram, Matteo Darmian and goalkeeper Raffaele Di Gennaro.
Although Francesco Pio Esposito celebrated his first senior goal for Italy last week, the strain of that international duty means he is rested in favour of Bonny as the partner to Lautaro Martinez upfront.
The rest of the line-up is first choice for Cristian Chivu, including Hakan Calhanoglu, Nicolò Barella and Manuel Akanji, so there is no squad rotation ahead of the Champions League.
Roma vs. Inter official line-ups
Roma: Svilar; Hermoso, Mancini, N’Dicka; Celik, Koné, Cristante, Wesley; Soulé, Pellegrini; Dybala
Inter: Sommer; Akanji, Acerbi, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Lautaro Martinez, Bonny