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Duke vs. Louisville odds, prediction, time: 2026 college basketball picks for Jan. 26 from proven model

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The No. 23 Louisville Cardinals take on the fifth-ranked Duke Blue Devils in a key ACC matchup on Monday night. Louisville is coming off an 85-71 win over Virginia Tech on Saturday, while Duke downed Wake Forest 90-69 that same day. The Cardinals (14-5, 4-3 ACC), who are tied for sixth in the conference, are 2-3 on the road this season. The Blue Devils (18-1, 7-0 ACC), who are 6-1 against ranked opponents, are 9-0 on their home court. Tipoff from Cameron Indoor Stadium in Durham, N.C., is set for 7 p.m. ET. Duke leads the all-time series 18-9, including a 5-3 edge in games at Durham. Duke is a 7.5-point favorite in the latest Louisville vs. Duke odds from DraftKings Sportsbook, while the...

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