The Latest: No. 1 Kerber loses in 1st round of French Open

Angelique Kerber is the first women's No. 1 seed to lose in the French Open's first round in the Open era.

There was another rapid exchange of breaks before Makarova sealed the result on her first match point with a forehand down the line after recovering from 40-0 down.

Stan Wawrinka, the 2015 French Open champion, told a press conference thatAgassi's return is "great for tennis" because "he's a great champion."

Top-ranked Angelique Kerber of Germany has lost the first set of her opening match at the French Open.

No female top-seeded player has ever lost in the opening round at Roland Garros in the Open era, which started in 1968.

The 31st-seeded Vinci, who ended Serena Williams' hopes of a calendar year Grand Slam by beating her in the semifinals at Flushing Meadows in 2015, lost 6-3, 3-6, 6-2 to Olympic champion Monica Puig.

Petra Kvitova has made a winning return to tennis as she became the first player to reach the second round of the French Open.

The year's second Grand Slam tournament started on the red clay of Roland Garros under a partly cloudy sky Sunday, with Kvitova getting things going in the main stadium in a first-round match against 86th-ranked Julie Boserup of the United States.

The French Open is set to start, and the featured match on Day 1 will be two-time Wimbledon champion Petra Kvitova's return to competition less than six months after being stabbed.