Serie A official line-ups: Juventus vs. Sassuolo
Juventus have Dusan Vlahovic back in the squad after four months, but Jeremie Boga starts with Kenan Yildiz and Francisco Conceicao against a Sassuolo side affected by a virus outbreak.
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It kicks off at the Allianz Juventus Stadium at 19.45 GMT (20.45 CET).
The Bianconeri are back in the hunt for a top four finish after the 3-3 thriller with Roma, then back-to-back victories over Pisa and Udinese.
The key was dropping Jonathan David for Boga as a False 9, flanked by Conceicao and Yildiz, so that is repeated here today with Boga facing his former club.
Emil Holm is now the only remaining absentee, because both long-term injury cases Vlahovic and Arek Milik are on the bench.
Mattia Perin keeps the gloves, with Khephren Thuram preferred to Teun Koopmeiners.
Sassuolo had a very strange build-up to this game, as six players were isolated after showing symptoms of whooping cough.
The identities of the players affected were not confirmed, with only one confirmed case of pertussis, which is an infection of the lungs and breathing tubes.
The Neroverdi had been on fine form until recently, then suffered back-to-back defeats with Lazio and Bologna.
Sassuolo were already missing injured Fali Candé, Alieu Fadera, Daniel Boloca and Edoardo Pieragnolo.
The players not in the squad are Nemanja Matic, Kristian Thorstvedt, Woyo Coulibaly and Stefano Turati.
These teams met on January 6, with Juve running out 3-0 winners away from home.
Juventus vs. Sassuolo line-ups
Juventus: Perin; Kalulu, Bremer, Kelly, Cambiaso; McKennie, Locatelli, Thuram; Conceicao, Boga, Yildiz
Sassuolo: Muric; Walukiewicz, Idzes, Muharemovic, Garcia; Bakola, Vranckx, Koné; Berardi, Pinamonti, Volpato