ALKYL CHAIN MODIFIED IMIDAZOQUINOLINE TLR7/8 AGONIST COMPOUNDS AND USES THEREOF

FIELD OF THE INVENTIONThe present disclosure relates to alkyl chain modified imidazoquinoline TLR7/8 agonist compounds for enhancing immune responses. The present disclosure also relates to pharmaceutical compositions comprising the alkyl chain modified imidazoquinoline compounds, methods of preparation thereof, methods for stimulating an immune response, and uses of the pharmaceutical compositions in the treatment of disease in a subject, e.g., infectious disease and cancer.BACKGROUND OF THE INVENTIONToll-like receptors (TLRs) are a family of transmembrane proteins that recognize structurally conserved molecules that are derived from and unique to pathogens, referred to as pathogen-associated molecular patterns. As such, TLRs function in the mammalian immune system as front-line sensors of pathogen-associated molecular patterns, detecting the presence of invading pathogens (Takeuchi and Akira 2010 Cell 140:805-820). TLR engagement in sentinel immune cells causes biosynthesis of select...