Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cells

Correspondence Open access Published: 07 February 2025 HyunJun Kang1na1, Dinh Hoa Hoang1na1, Melissa Valerio1, Khyatiben Pathak2, William Graff3, Alexis LeVee4, Jun Wu5, Mark A. LaBarge6, David Frankhouser7, Russell C. Rockne7, Patrick Pirrotte2, Bin Zhang1, Joanne Mortimer4, Le Xuan Truong Nguyen1,2 & …Guido Marcucci1 volume18, Articlenumber:16 (2025) Cite this article 386 Accesses Metrics details AbstractNatural products have long been a viable source of therapeutic agents, providing unique structures and mechanisms that may be beneficial for cancer treatment. Herein we first report on the anticancer activity OST-01, a natural product from Baccharis Coridifolia, on breast cancer cells, including triple-negative breast cancer (TNBC). OST-01 significantly inhibited cell proliferation and oncogenic activities of TNBC cells in vitro. OST-01 also markedly inhibited TNBC tumor growth in vivo, with > 50% reduction in tumor size compared to vehicle control treatment in different in vivo mode...