Antipyretic and Anti-inflammatory Effects of Sanchen Pediatric Antipyretic Paste

Abstract Objective: This study aimed to investigate the antipyretic and anti-inflammatory effectsand mechanisms of Sanchen Pediatric antipyretic Paste (SPAP).Methods: Rats were randomly divided into 7 groups: negative control group, positive control group,positive treatment group, SPAP high-dose, medium-dose and low-dose groups, and blank substrategroup. Except normal control group, rats in other groups were subcutaneously injected with 10% dryyeast suspension (10 mL/kg) on the back to establish a fever model, and the normal group was giventhe same volume of saline. At the 4 h and 7 h after modeling, each treatment group was subjected tocorresponding SPAP intervention. Anal temperature was measured every one hour after modeling for10 consecutive times. The average temperature-rise curve, maximum temperature and body temperatureresponse index (TRI) were calculated to evaluate the efficacy of SPAP. After the last temperaturemeasurement, abdominal aortic blood was collected, and serum was...