A Heisman-winning quarterback faces a defense that eats passers alive.

Clemson passed a major test in Week 2 after bullying Auburn up and down the field in a 14-6 victory. Things won’t get much easier this Saturday, however. The Tigers will head to Kentucky for a top-15 showdown with Louisville, broadcast live on ABC starting at 8 p.m. ET (live stream).

Clemson’s quest to defend its 2016 national title got off to a hot start after sacking Auburn quarterback Jarrett Stidham 11 times to shut down the Tigers’ offense. On Saturday night, they’ll face an even tougher test when 2016 Heisman Trophy winner Lamar Jackson lines up in the Louisville backfield with revenge on his mind; the Tigers handed the Cardinals one of only four losses last fall -- an early-season defeat that derailed the program’s national championship hopes and hype.

Time, TV channel, and streaming info

• Time: 8 p.m. ET
• Location: Papa John’s Stadium, Louisville, Ky.
• TV: ABC
• Streaming: WatchESPN
• Odds: Clemson is favored by 3 points.

Clemson vs. Louisville news:

• Here’s a breakdown of all 11 (!) Clemson sacks against Auburn, in all their deflating glory.

There were plenty of questions about Clemson coming into the season, but most of them were on offense. Nobody in their right mind could question the destructive nature of the team’s front seven, and it was on full display against Auburn.

Let’s roll sack-by-sack through the game and show how and why you should still fear Clemson’s defense.

• Last week’s big win over Auburn did nothing to quell concerns about the Clemson offense.

We have a lot to fix on offense, but I’m reminded that Clemson struggled offensively against Auburn last year as well. DW struggled against Kevin Steele and his scheme. First Kelly Bryant didn’t turn the ball over or throw an interception. That is huge. He threw one ball late down low to Richard that was a poor decision, but other than that everything was safe.

• The Cardinals will be without senior tailback Jeremy Smith, who fractured his toe.

Smith, who carried five times for eight yards in the season-opener against Purdue, suffered the injury during practice last Thursday.

Smith had been a contributor for Louisville during each of his first two seasons with the Cardinals. He carried 57 times for 382 yards and eight touchdowns in 2015, and 60 times for 270 yards and three scores a season ago.

• How big is Saturday’s game? College GameDay big.

“GameDay” also came to PJCS in week three a year ago. On that day, Louisville erupted for 63 points in a 63-20 thrashing of visiting second-ranked Florida State.

Does Lamar Jackson’s Heisman repeat campaign end here?

Clemson made Stidham look stupid last week, punishing him for holding on to the ball for even a split second longer than needed and driving him into the turf with impunity. Stidham, however, isn’t nearly as active as Jackson, who can negate the Tigers’ bull rush with his uncanny ability to scramble from the pocket. The 2016 Heisman winner ran for 1,852 yards last fall and 239 yards to start this season — but he’ll face the toughest test of his career against Dabo Swinney’s relentless defense.

Clemson vs. Louisville prediction:

Louisville’s offense isn’t a problem -- but its defense might be. The Cardinals allowed Purdue to put up 28 points in their season opener before North Carolina rolled up 35 more in Week 2. Expect Clemson to take advantage of that weakness while doing just enough from keeping Jackson from burning them to cinders. The defending champions win this one in a slugfest.